Abstract
A study was undertaken to determine the effect on blood and tissue lipids of rabbits fed a low fat diet containing three levels of calcium, <0.02%, 0.8%, and 1.6%. Plasma cholesterol and phospholipids were elevated in the group fed the calcium-deficient diet,whereasplasmatriglycerides appearedtobe unaffected by the level of calcium fed. Lipid levels of tissues also varied depending on the amount of calcium in the diet. In calcium deficiency, liver showed an elevation of cholesterol and phospholipid whereas lung showed decreased levels of these lipids. When the rabbits were fed the high calcium diet, heart, skeletal muscle, and adrenal gland showed signffi cant decreases in free cholesterol, but only skeletal muscle showed a decrease in total phospholipids with high calcium supplementation. Tissue triglycerides varied inde pendently of cholesterol and phospholipids. Increases in the levels of triglycerides of kidney, skeletal muscle, and adrenal gland were observed with increasing increments of dietary calcium. The role of calcium on tissue lipids appears widespread and warrants further investigation. J. Nutr. 104: 1165â€1171, 1974.
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