Abstract
In the rat, adriamycin increased stasis-induced thrombosis in a dose- and time-dependent manner. Two potent antiplatelet agents, clopidogrel ( 20 mg/kg, po ) and aspirin ( 200 mg/kg, po ) showed a strong antithrombotic efficacy ( 92 and 77 % inhibition of thrombus formation respectively ) therefore suggesting that platelets play a major role in the prothrombotic effect of adriamycin. Standard heparin, administered as a single bolus injection ( 3 mg/kg, iv ), 5 min prior to stasis did not affect adriamycin-induced thrombosis whereas hirudin ( 1 mg/kg, iv ) suppressed thrombus formation ( 98% inhibition ). SR 27417, a potent PAF receptor antagonist injected iv, reduced venous thrombosis in a dose-dependent manner ( 14, 29 and 63% inhibition after 1, 3 and 6 mg/kg respectively ). These results therefore demonstrate that adriamycin-induced venous thrombosis is highly dependent upon platelet activation.
Published Version
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