Effect of vancomycin complex antibiotic cement implantation in the treatment of postoperative infection in orthopedics

Abstract

Objective To investigate the efficacy of vancomycin combined with antibiotic bone cement implantation in the treatment of common infections in orthopedics. Methods From February 2014 to February 2016, total of 429 patients with orthopedics infection in our hospital were divided into experimental group (215 cases with vancomycin combined antibiotic bone cement implantation surgery) and the control group (214 cases with CEMEX GEN antibiotic bone cement implantation surgery) randomly. The experimental results were collected according to the follow up indexes and cure standard, which were analyzed by statistical methods. Results The curative effect of traditional debridement plus vancomycin composite antibiotic bone cement implantation therapy to treat orthopedics infection was better compared with single type antibiotic bone cement implantation (using gentamicin antibiotic), the cure rate of the former was 89.77%, while the cure rate of the latter was only 37.85%, with significant difference (χ2 = 12.363, P = 0.024), but the postoperative complications of two treatment methods were without significant difference (χ2 = 5.710, P = 0.074). Conclusions The curative effect of vancomycin combined with antibiotic bone cement implantation to treat orthopedics infection was much better than that of single antibiotic bone cement implantation. Key words: Vancomycin; Compound antibiotic bone cement; Department of orthopedics infection; Clinical effect