Abstract
Objective To study the effect of negative pressure of vacuum sealing drainage (VSD) on the healing of Staphylococcus aureus-infected wounds in the soft tissue of pigs.Methods Thirty-two Staphylococcus aureus infection models of skin and soft tissue wounds were established,and randomly and equally divided into four groups as control group (with conventional dressing) and three VSD treatment groups according to the negative pressure as-10,-25,and-50 kPa of drainage respectively.Pre-and post-treatment biopsy was performed from the center of the wounds for pathologic observation and bacteria counting.Results As compared with VSD groups,the wound in the control group(P ＜ 0.01) got higher bacteria counts,more secretions,more yellow colored tissues,obvious edema around the wound,and longer healing time.Conclusion Degative pressure of VSD can reduce the secretion of the wound,inhibits the growth and proliferation of Staphylococcus aureus,stimulate the formation of granulation tissue and thus shorten the time for wound healing. Key words: Vacuum sealing drainage; Infection ; Staphylococcus aureus ; Wound healing
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