Effect of Vacuum Contact Agitated Drying on Particle Size Distribution of Aspirin Powder and Aspirin Agglomerates

Zainab Ibrahim S G Adiya,Bintu Grema Mustafa

doi:10.34198/ejcs.5121.7785

Abstract

Experiments have been carried out to study the effect of agitation on particle size distribution of aspirin powder and aspirin agglomerates during vacuum contact agitated drying. Morphology G3 by Malvern was used to find the size distribution of the materials under investigation before and after the drying process at 0.1, 0.5 and 0.9 µm. It was found that due to agitation, aspirin powder portrayed from negligible to significant agglomeration dependent on the diameter of the material under investigation. While attrition and agglomeration compete together during the drying process of aspirin agglomerates, with attrition dominating at 0.1 and 0.5µm and agglomeration at 0.9 µm.

Highlights

One of the mandatory steps involved in the preparation of many pharmaceutical products is the removal of water or solvents [1], known as drying [2, 3]
The aim of this study is to investigate the effect of vacuum contact agitated drying on particle size distribution of aspirin powder and aspirin agglomerates
The specific objectives of the research are to; (1) study the drying behaviour of aspirin powder and aspirin agglomerates in laboratory scale agitated filter dryer (AFD) using vacuum contact agitated drying (2) compare and contrast the drying behaviour of aspirin powder and aspirin agglomerates with respect to drying time and drying rate using vacuum contact agitated drying at exactly same operational conditions and (3) to find the effect of vacuum contact agitated drying on particle size distribution of aspirin powder and aspirin agglomerates after drying using morphology G3 by Malvern at exactly same operating conditions

Summary

Introduction

One of the mandatory steps involved in the preparation of many pharmaceutical products is the removal of water or solvents [1], known as drying [2, 3]. The removal of water through drying has many advantages [4] including but not limited to easy handling and storage, lower transportation costs, and improved stability. Dehydration is the common objective shared by most drying techniques even though these techniques are conceptually different and require modification/ adaptation depending on the type and properties of the compound. G. Adiya and Bintu Grema Mustafa powder or cake involves the removal of water and this is done through the application of heat during drying, via conduction, convection, and/or radiation to vaporize water or other solvents [3, 5, 6]. Forced air or vacuum may be applied in addition to the heat to improve the rate of dehydration

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Conclusion