Abstract
After intraperitoneal injection of 4-methyluracil (4MU) and 4-methyl-5-hydroxy-uracil (4M5HU) for four days in doses of 100 mg/kg daily partial inhibition of malate- and succinate-dehydrogenase activity was found in the liver mitochondria. The utilization of inorganic phosphate for ATP resynthesis was inhibited, and this was evidently one cause of the decrease in the ATP content in the liver. Administration of 4M5HU in a dose of 30 mg/kg was accompanied by similar changes but they were less marked. Under the influence of 4 MU in a dose of 30 mg/kg only the rate of phosphorylation in the mitochondria and the ATP content in the liver were significantly changed (increased).
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