Abstract
Abnormal sodium excretion by the kidneys contributes to the pathogenesis of essential hypertension. We studied the effect of upright posture on natriuresis and hormone level after a saline infusion in 8 normotensive men (23±2years old<mean±SE>) and 14 men with mild essential hypertension (25±2years old) with normal plasma renin. All subjects were hospitalized and placed on a diet containing sodium chloride at 6g per day. Physiological saline was infused intravenously during 120min at a rate of 8.3mL·min−1, while we measured urinary sodium excretion (UNaV), endogenous creatinine clearance (CCr), renal blood flow (RBF), calculated from p-aminohippuric acid clearance and hematocrit, plasma noradrenalin concentration (PNE) and atrial natriuretic peptide concentration (PANP).
Published Version
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