Abstract
The effect of unilateral perinatal hypoxic-ischemic brain injury on striatal dopamine uptake sites and on D 2 and D 2 receptors was investigated in rat by using in vitro quantitative receptor binding autoradiography, 9–11 weeks after the insult. Saturation experiments revealed a significant 20% decrease in maximal binding capacity ( B max) for [ 3H]spiperone-labeled D 2 receptors on the side of the lesion in comparison to the non-lesioned contralateral side or to either side of control animals. There was no significant change in [ 3H]mazindol-labeled dopamine uptake sites or in [ 3H]SCH 23390-labeled D 1 receptor characteristics ( B max and K d) on the lesioned side. We conclude that the decrease in D 2 receptor binding previously observed in immature animals is persistent, whereas the decrease in D 1 binding is not.
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