Abstract
The immediate effect of added inspiratory elastic loads on breathing was studied in seven anesthetized, tracheotomized cats before and after unilateral and bilateral vagotomy. Unilateral and bilateral vagotomy resulted in a progressive decrease in the ability of the respiratory system to maintain stability of tidal volume in the face of the added elastic loads, the opposite being true for respiratory frequency. Ventilatory stability to added inspiratory elastic loads remained virtually unchanged following either unilateral or bilateral vagotomy. Changes in the stability of tidal volume before and after unilateral and bilateral vagotomy were closely related to changes in the contribution of the vagal lung volume-related feedback control of inspiratory duration and total breath duration.
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