Effect of ultrasound-guided transverses abdominis plane block on analgesic efficacy of patients undergoing colon cancer radical surgery

Abstract

Objective To evaluate the postoperative analgesic efficacy of transversus abdominis plane (TAP) block in patients undergoing colon cancer radical surgery. Methods There were 96 patients who underwent colon cancer radical surgery, with no gender restriction and USA society of anesthesiologists score standard (ASA) grade Ⅰ-Ⅲ. They were randomly divided into 2 groups: control group (C group C) and observation group (TAP group). The control group was only given routine general anesthesia, while the observation group was treated with ultrasound guided TAPB on the basis of the control group. The changes of mean arterial pressure, surgical pleth index, heart rate, entropy index, inhaled sevoflurance concentration and sufentanil in the two groups were observed at the baseline (T1), skin incision (T2), 5 min after skin incision (T3), 30 min after skin incision (T4), and sewn skin (T5). At four postoperative time points: 30 min(T6) after extubation, postoperative 6 h (T7), postoperative 24 h (T8), postoperative 48 h (T9), the Internet of things plus-wireless analgesia system automatically recorded postoperative dosage of patient controlled intravenous analgesia (PCIA) sufentanil and postoperative analgesic efficacy was followed up blindnessly by a specially-assigned person. Results As compared with C group, at T3 (0.64±0.11) vs. (0.71±0.12) μg/kg, T4 (0.66±0.15) vs. (0.81±0.15) μg/kg, T5 (0.70±0.12) vs. (0.93±0.15) μg/kg, T6 (0.99±0.12) vs. (1.07±0.19) μg/kg, T7 (1.35±0.20) vs. (1.49±0.16) μg/kg, T8 (2.00±0.42) vs. (2.25±0.31) μg/kg, T9 (2.67±0.50) vs. (3.27±0.47) μg/kg, dosages of sufentanil in TAP patients decreased (P=0.006, 0.000, 0.000, 0.027, 0.001, 0.002, 0.000), and the patients for deficiency of analgesia decreased from 17 cases to 8 at T8 (χ2=4.381, P=0.036). Conclusion Ultrasound guided TAP block combined with general anesthesia can improve the analgesic efficacy intraoperatively and postoperatively in radical resection of colon cancer. Key words: Ultrasonic guidance; Transverses abdominis plane; Colon cancer surgery; Patient controlled intravenous analgesia