Abstract
By employing a laser-Doppler flowmeter, an investigation was performed to determine whether ultrasound causes a change in regional cerebral blood flow (rCBF). rCBF in neonatal rats (age: 2–6 days postgestation) was measured before, during, and after exposure of both cerebral hemispheres to continuous-wave ultrasound (1.0 MHz) at an intensity of 2.0 W/cm 2 (SATA) for a period of 5 min. After 3 min of ultrasound treatment, there was a statistically significant augmentation in rCBF (p < 0.05) with rCBF increasing by a factor of 2.7 ± 0.4 (mean ± SEM) after 5 min of ultrasound. This response was demonstrated to be a transient effect, because rCBF returned to its original value 4–6 min after termination of the ultrasound treatment.
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