Abstract
Background/aim Applications of ultrasound in medicine for therapeutic purposes have been an accepted and beneficial use for many years. The present study aimed to investigate the harmful effect of exposure to therapeutic ultrasound on the cornea and the possible protective role of ascorbic acid and β-carotene. Materials and methods A total of 50 healthy mature New Zealand albino rabbits were enrolled in this study and classified into four groups. Group I contained five rabbits and were used as a control group. The remaining rabbits were classified into three groups of fifteen rabbits each. The eyes of group II were insonificated with continuous ultrasound waves (1.5 W/cm2 at 2.8 MHz) for 20, 40, and 60 min. Group III and group IV were topically treated with vitamin C and supplemented with β-carotene, respectively, before insonificated with ultrasound for 20, 40, and 60 min. All the rabbits were decapitated 24 h after ultrasound exposure. Total soluble protein content and Fourier-transform infrared (FTIR) analyses were carried out on cornea. Results Soluble protein content of cornea recorded highly significant decreased (P Conclusion Ultrasound waves have the possibility to cause significant change in the molecular structure of corneal tissue. The use of antioxidants such as vitamin C and β-carotene preserves the corneal tissue, especially at short insonification time.
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