Abstract
The biological activities of Angelica gigas Nakai can be improved using water extraction at 60°C with ultra-sonication. Conventional water extraction at 100°C can destroy heat labile active compounds in medicinal herbs. A high frequency (200 kHz) (actual intensity, 210 W/m2) minimally affected the extraction yield at 40°C. A low frequency (40 kHz) (50 W/m2) at 60°C produced better results. A. gigas Nakai extracts produced using a low frequency showed a 50% increase in human immune cell growth and IL-6 secretion, compared to conventional water extraction extracts. Extracts produced using 40 kHz and 60°C produced more immune B and T cell growth than 40°C extracts. These results were confirmed using similar HPLC chromatogram peak patterns at input intensities of 50 and 210 W/m2. A better than 50% extraction yield and cytokine secretion increase, and better immune cell growth, was achieved in ultrasonication extracts produced at low temperatures.
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