Effect of ulinastatin combined with glutamine on severe acute pancreatitis and effect on serum inflammatory cytokines and liver and kidney function

Abstract

Objective To analyze the curative effect of ulinastatin combined with glutamine on severe acute pancreatitis and effect on serum inflammatory cytokines and liver and kidney function. Methods Sixty-eighty patients with acute severe pancreatitis were selected from October 2014 to April 2016. According to the different intervention programs, they were divided into control group (n=34) and study group (n=34). The control group received routine intervention, the study group received ulinastatin combined with glutamine intervention on the basis of control group. Both of the two groups were continuously treated for 14 days. The clinical efficacy and adverse reactions of the two groups were observed. The serum inflammatory factors [high-sensitivity C-reactive (hs-CRP) protein before and after treatment, tumor necrosis factor alpha (TNF-α) and interleukin -6 (IL-6), interleukin -8 (IL-8)], liver and kidney function index [serum creatinine (Scr), blood urea nitrogen (BUN) and aspartic acid transaminase (AST), alanine aminotransferase (ALT), total bilirubin (TBIL)] levels were compared. Results The total effective rate of the study group (94.12%) was significantly higher than that of the control group (73.53%), and the difference was significant (P 0.05); after treatment, IL-6 [(4.23±0.21) ng/ml], IL-8 [(10.24±1.01) ng/ml], TNF-α[(8.87±1.11) ng/ml], hs-CRP [(0.87±0.09) mg/ml], Scr [(100.76±9.01) μmol/L], BUN [(4.76±0.77) mmol/L], AST [(23.76±2.20) U/L], ALT [(24.81±4.12) U/L], TBIL [(12.10±1.21) μmol/L] in the study group were better than those in the control group, the differences were significant (P 0.05). Conclusions The curative effect of ulinastatin combined with glutamine on severe acute pancreatitis is definite, which can effectively relieve clinical symptoms, reduce the serum level of expression of inflammatory cytokines, improve liver and kidney function, and high safety. Key words: Ulinastatin; Glutamine; Severe acute pancreatitis; Inflammatory factor; Liver and kidney function