Abstract

BackgroundThe macrolid antibiotic tylosin has been widely used to treat canine chronic diarrhea, although its efficacy is based on anecdotal reports and experimental studies in dogs and not on strong scientific evidence. The term tylosin-responsive diarrhea (TRD) refers to diarrheal disorders responding to tylosin therapy within a few days. In TRD, the stool remains normal as long as tylosin treatment continues, but diarrhea reappears in many dogs within weeks after discontinuation. The aim of our trial was to assess the effect of tylosin on fecal consistency compared with a placebo treatment in dogs with suspected TRD and additionally to establish whether tylosin in dogs with recurrent diarrhea is as effective as empirical studies and anecdotal reports suggest.MethodsSubjects comprised 71 client-owned dogs that, according to the owners, had previously been treated successfully with tylosin due to recurrent diarrhea of unknown etiology. At the initial examination, where there were no signs of diarrhea, the dogs were randomly assigned in a 2:1 ratio to a tylosin or placebo group. During a two-month follow-up the owners evaluated the fecal consistency according to previously published guidelines. When diarrhea recurred, either tylosin (25 mg/kg q 24 h, 7 days) or placebo treatment was initiated orally. Treatment outcome was evaluated as the mean of fecal consistency scores assigned during the last three days of the treatment period. To test for differences between the tylosin and placebo group in the proportion of responders, Pearson's Chi-squared test and Fisher's exact test were applied.ResultsSixty-one dogs met the selection criteria and were followed for two months. During the follow-up 27 dogs developed diarrhea and either tylosin or placebo treatment was started. The proportion of dogs with normal fecal consistency at the end of treatment was 85% (17/20) in the tylosin group and 29% (2/7) in the placebo group (Pearson's Chi-squared test p = 0.0049 and Fisher's exact test two-sided, p = 0.0114).ConclusionsOur findings indicate that tylosin is effective in treating recurrent diarrhea in dogs. The dose of 25 mg/kg once daily appears sufficient. No changes specific to TRD were detected in the examinations.

Highlights

  • The macrolid antibiotic tylosin has been widely used to treat canine chronic diarrhea, its efficacy is based on anecdotal reports and experimental studies in dogs and not on strong scientific evidence

  • The effect of tylosin was shown to differ from that of other antibiotics, and the term tylosin-responsive diarrhea (TRD) was proposed for diarrheal disorders responding to tylosin therapy within a few days [1,2]

  • In 34 dogs, diarrhea did not recur during the follow-up period, and they were released from the study (Figure 2)

Read more

Summary

Introduction

The macrolid antibiotic tylosin has been widely used to treat canine chronic diarrhea, its efficacy is based on anecdotal reports and experimental studies in dogs and not on strong scientific evidence. The term tylosin-responsive diarrhea (TRD) refers to diarrheal disorders responding to tylosin therapy within a few days. The effect of tylosin was shown to differ from that of other antibiotics, and the term tylosin-responsive diarrhea (TRD) was proposed for diarrheal disorders responding to tylosin therapy within a few days [1,2]. The owners of the dogs reported that even after several treatments the effect of tylosin was as good as at the initial treatment This is astonishing, as tylosin is an antibiotic substance, and long-term usage of antibiotics generally contributes to the development of microbial resistance. Achieving a positive antibiotic treatment is even more difficult if the same antibiotic is used repeatedly to treat the same disease in the same individual

Methods
Results
Discussion
Conclusion
Full Text
Paper version not known

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.