Effect of two anesthesia methods on inflammatory factors and cognitive function in patients undergoing knee replacement

Abstract

Objective To investigate the effects of two anesthesia methods on inflammatory factors and cognitive function in patients undergoing knee replacement. Methods From January 2016 to May 2019, 40 patients over 60 years old who underwent knee replacement in the First Affiliated Hospital of Guangzhou Medical University were randomly divided into the study group and the control group, 20 patients each. The patients with preoperative mental impairment were excluded. The study group were treated with laryngeal mask general anesthesia combined with femoral nerve block, and the control group were treated with general anesthesia. The serum levels of tumor necrosis factor(TNF)-α and interleukin(IL)-6 were compared before operation and at the postoperative 24 h, the postanesthesia care unit (PACU)recovery time of all patients were observed and recorded, and the mini-mental state examination(MMSE) scale wasused to evaluate the cognitive function in the two groups before operation and postoperative 1, 3 and 7 d. All the data were compared using t test. Results The levels of TNF-α、IL-6 of the study group were lower than that in control group at 24 h postoperation(t=10.025、8.117, P 0.05). Conclusion For the patients undergoing knee replacement, laryngeal mask general anesthesia combined with femoral nerve block can decrease the levels of inflammatory factors, promote rapid recovery, and improve the postoperative cognitive disfunction in short period, which is worthy of further clinical application. Key words: Anesthesia, general; Nerve block; Cognitive dysfunction; Inflammation; Cytokines