Abstract
In this study, we determined whether Tunisian aromatic plants can induce melanogenesis in the cultured mouse melanoma cell line, B16. The cells were cultured with or without Tunisian aromatic plant extracts. We found that melanogenesis was enhanced by Tunisian aromatic plant extract without affecting cell growth and cell shape. This denotes that Tunisian aromatic plant can induce melanogenesis in B16 cells without causing transformation. In succeeding experiments, we found that Tunisian aromatic plant promoted melanogenesis without affecting tyrosinase protein expression. Moreover, we did not detect the phosphorylation of extracellular signal-regulated kinase 1 and 2 (ERK1/2), which are related to inhibition of melanogenesis.
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