Abstract
Blood plasma contains a tetrapeptide known as tuftsin (Thr-Lys-Pro-Arg), which stimulates phagocytic activity. In low concentrations it increases the phagocytic activity of polymorphonuclear leukocytes from the peritoneal cavity of guinea pigs [9] and also macropha~es from the mouse peritoneal cavity and rabbit lung [9]. In the presence of tuftsin the bactericidal ability of macrophages is increased by two-three times [9]. Tuftsin considerabJy increases migration of both macrophages and lymphocytes, and stimulates processes of chemotaxis [15] and other functions of T helper and B cells. There are indications that tuftsin may participate in the programming of lymphocytes, possibly through its effect on macrophages [ii]o
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