Abstract
Background and Objective:Trimetazidine has mainly been used in coronary insufficiency, angina and elderly myocardial infarction. However, the effect of trimetazidine on the efficacy, heart rate variability (HRV) and protection of myocardial ischemia in elderly patients with acute coronary syndrome (ACS) remains unclear. This study aimed to investigate the effect of trimetazidine on the efficacy HRV and protection of myocardial ischemia in patients with ACS.Methods:One hundred twenty two elderly ACS patients who were above 70 years were chosen and randomly divided into two groups. One group was given conventional therapy, such as aspirin, isosorbide mononitrate and fluvastatin, and the other group was administered trimetazidine in addition to conventional therapy. The treatment period was eight weeks. A PI-2.22B three-channel AECG system was used on every patient for 24 hour dynamic electrocardiogram monitoring and HRV analyses on the first day after admission and eight weeks after treatment. HRV, 24 hour RR intermediate stage standard deviation (SDNN), five minutes average normal cardiac cycle standard deviation in 24 hour (SDANN), 24 hour close together normal cardiac cycle difference value mean square root (rMSSD), the percentage of difference of close together RR intermediate > 50 ms account total RR intermediate (PNN50), high frequency (HF) and low frequency (LF) parameters of patients were observed before and after treatment.Results:The SDNN, SDANN, rMSSD, PNN50 and HF parameters significantly increased compared with the conventional treatment group (all P < 0.05). LF and LF/HF were significantly decreased in the trimetazidine treatment group compared with those in the conventional treatment group (all P < 0.05).Conclusion:Trimetazidine improves HRV of elderly ACS patients and reduces cardiovascular events.
Highlights
Acute coronary syndrome (ACS) includes unstable angina (UA) and acute myocardial infarction (AMI)
The clinical symptoms of patients with UA and NSTEMI were relieved, ST segment depression was improved and the extent of myocardial ischemia was significantly reduced in the trimetazidine treatment group compared with those in the conventional therapy group
acute coronary syndrome (ACS), which includes unstable angina, non-STelevation myocardial infarction and ST-segment elevation myocardial infarction, is a syndrome of a group of coronary heart disease (CHD). This group includes coronary atherosclerosis plaque rupture, haemorrhage, thrombosis, coronary spasm, severe stenosis, trauma and mezzanine as the basic pathophysiological characteristics, with the common characteristics of necrosis or acute myocardial ischemia caused by increasing myocardial consumption of oxygen, leading to hyperpyrexia, severe anaemia and hyperthyroidism
Summary
Acute coronary syndrome (ACS) includes unstable angina (UA) and acute myocardial infarction (AMI). Trimetazidine, with its chemical name trimetazidine, 3-KAT depressantia, is an antiheart muscle ischemia drug that has mainly been used in coronary insufficiency, angina and elderly myocardial infarction. Trimetazidine has mainly been used in coronary insufficiency, angina and elderly myocardial infarction. The effect of trimetazidine on the efficacy, heart rate variability (HRV) and protection of myocardial ischemia in elderly patients with acute coronary syndrome (ACS) remains unclear. This study aimed to investigate the effect of trimetazidine on the efficacy HRV and protection of myocardial ischemia in patients with ACS. Results: The SDNN, SDANN, rMSSD, PNN50 and HF parameters significantly increased compared with the conventional treatment group (all P < 0.05). Conclusion: Trimetazidine improves HRV of elderly ACS patients and reduces cardiovascular events
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