Effect of triiodothyronine supplementation on thyrotropin-releasing hormone-induced growth hormone secretion in sex-linked dwarf and normal chicks

Abstract

The effect of a dietary triiodothyronine (T 3) supplement, of either 0.1 or 0.5 μg/g of feed, was studied on the thyrotropin-releasing hormone (TRH)-induced growth hormone (GH) secretion in sex-linked dwarf ( dw) or normal ( Dw) chicks of both sexes. In normal chicks, 0.1 μg/g T 3 decreased plasma GH levels before TRH as well as the GH increase after TRH, and 0.5 μg/g T3 totally suppressed any response to TRH, either at 4 or at 7 weeks of age. Dwarf chicks were more sensitive to TRH than normals when receiving either 0 or 0.1 μg/g T 3; 0.5 μg/g T 3 abolished the difference between genotypes at 4 weeks of age but not so clearly at 7 weeks of age, where dwarf females showed a slight but still significant GH increase after TRH. Interactions between genotype, TRH injection, and T 3 treatments were often significant at 4 weeks of age and even more at 7 weeks of age. Dwarf chicks receiving 0.1 μg/g T 3, expected to have normal plasma T 3 levels, showed a higher GH response after TRH. This suggests that other hormones may be involved in the regulation of this response, particularly IGF-I, which is known to remain at a low level in T 3-treated dwarf chicks.