Abstract
Mice infected with <i>Trichinella spiralis</i> have shown resistance to both intravenous and intraperitoneal infection with <i>Listeria monocytogenes</i>. Since protection against <i>L. monocytogenes</i> is mediated by cellular immunity, the effect of infection with <i>T. spiralis</i> on the immune response to BCG was investigated. ICR/CD<sub>1</sub> mice were infected with 200 <i>T. spiralis</i> at 14, 56, 98 and 112 days preceding intravenous administration of 4 × 10<sup>6</sup> viable BCG. Groups were tested for delayed hypersensitive foot pad responses 28 days following BCG inoculation. All mice receiving <i>T. spiralis</i> and BCG exhibited a marked potentiation of the 24-hour foot pad response to Old Tuberculin over that shown by the appropriate controls.
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