Abstract
An alteration of metabolism of C 14-labeled amino acids into serum and hemoglobin was observed when glycine, alanine, tyrosine, and tryptophan were fed to Trichinella-infected mice. An initial fall in serum C 14 specific activity and subsequent rise was observed as duration of the infection was extended from 14 to 180 days. The observed changes in concentration of C 14 in serum and hemoglobin appear to be related to the influence of the infection on various amino acid transaminase and decarboxylase enzyme systems. dl-Tryptophan-2-C-14 was incorporated into hemoglobin of 180-day infected mice in a tenfold increase over that found in normal mice. A 20% increase in C 14 activity was found in the serum. In all 180-day infected mice the serum free-amino acid carboxyl carbon levels rose above those of normal mice, indicating a decrease in utilization of serum free amino acids.
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