Abstract
Depressive disorder is a common serious mental illness, with significant disability rate and mortality, which has caused serious burden to society and family. At present, nearly half of the depressive patients are unable to get effective treatment. In clinical practice, ketamine was widely observed to alleviate depressive symptoms effectively. However, its antidepressant mechanism is not clear. Focusing on the progresses in antidepressive mechanism of ketamine, this review summarizes the complex interaction mechanism about acute and delayed effect of ketamine, and puts forward the feasible scheme of design based on the existing literatures and previous researches, which aims to provide scientific basis for clinical application of ketamine as an antidepressant. Key words: Ketamine; Depressive disorder; Time; N-methyl-D-aspartic acid receptor
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
