Abstract
309 The effect of intraarterial administration of lidocaine, prostaglandine E1 or chlorpromasine on renal blood flow, parenchymal microcirculation and post-ischemic function after acute warm kidney ischemia was investigated. Seventy rats, uni-nephrectomised one month before investigation, were operated under general anaesthesia. Renal vessels were occluded for 90 minutes. Animals were divided into groups of ten rats each. Rat in the first group received 200 μg/kg/min of PGE1, in the second - lidocaine 1 mg/kg in bolus followed by 0.1 mg/min, and in the third - chlorpromasine 2 mg/kg intraarterialy in bolus followed by 0,06 mg/kg infusion during 30 min prior to renal vessels occlusion. Groups IV, V and VI received the same doses of PGE1, lidocaine or chlorpromasine during 30 min after revascularisation. The control groups were treated the same way with 1ml 0,9% NaCl. Renal blood flow (RBF) was measured using ultrasound Doppler flowmeter, renal cortical blood flow (CBF) was measured with laser-doppler flowmeter. Vascular resistance (VR) was calculated from the blood flow and mean arterial pressure. Rats were observed for 21 days in metabolic boxes; serum creatinine concentration and clearance were measured. Results. Mean results of RBF, CBF and VR in all groups 60 min after revascularisation (table). The highest RBF as well as CBF and lowest VR after revascularisation and complete recovery to pre-clamping values were observed after pre-clamping PGE1 administration. Return to normal creatinine and clearance values was better in this group and nine of ten rats survived the experimentTableConclusions. The highest renal blood flow and cortical flow were observed after pre-clumping PGE1 administration and they correlated with the best post-operative kidney recovery. Despite slightly worse results after lidocaine administration its effect deserves attention due to its incomparably lower cost.
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