Abstract
The current study investigated the effect of administration of vitamin E (600mg / kg diet) concomitantly with lead acetate (10mg /kg, orally) and vitamin C (100mg /kg, orally) concomitantly with lead acetate (10mg /kg, orally) to the female lactating rats on the neurobehavioral, landmarks development and some biochemical tests in their pups. Administration of lead acetate to the female lactating rats caused a significant increase in open field activity test including (the number of squares crossed and rearing test within 3 minutes), olfactory discrimination test, triglycerides and malondialdehyde brain tissue, with a significant decrease in glutathione brain tissue and high density lipoproteins in their pups. The present study demonstrated that treatment of female lactating rats with vitamin C and lead acetate produced a significant decrease in righting reflex test in their pups. Administration of vitamin E concomitantly with lead acetate to the female lactating rats caused a significant increase in glutathione level accompanied with a significant decrease in malondialdehyde and triglycerides levels in their pups. The present study showed that treatment of female lactating rats with vitamin E or C with lead acetate produced a significant decrease in rearing test, whereas a significant increase in high density lipoproteins in their pups. It is concluded that administration vitamin E or C to the female lactating rats reverse the adverse effects produced by lead acetate on neurobehavioral. Vitamin E had positive effect on the levels of glutathione, malondialdehyde brain tissue, triglyceride and high density lipoproteins in their lactating pups.
Highlights
Lead is an ubiquitous element in the environment, it is used in many industrial activities including mining, refining and producing lead – acid batteries [1]
Treatment with vitamin E to the rats receiving lead acetate during lactation period did not effect significantly the onset of movement and negative geotaxis tests in their pups, but the treatment with vitamin C to the rats receiving lead acetate during lactation period produced a significant increase (P≤0.05) in the onset of movement test
The present study showed that administration of lead acetate to rats during lactation period caused a significant increase in the open field activity test including and olfactory discrimination test in their pups compared to pups of the control group
Summary
Lead is an ubiquitous element in the environment, it is used in many industrial activities including mining, refining and producing lead – acid batteries [1]. This heavy metal is less widely used today, it remains a significant public health problem. Milk is the most important food source for newborn, be a pathway of maternal excretion of toxic elements such as lead, and these toxins impact most severely on the newborn at a time of rapid development of the central nervous system [5]. The main targets organ of lead toxicity are the red blood cell, central nervous system, peripheral nerves and the kidney [11]
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