Abstract
Acute and chronic brain ischemia in dogs with rehabilitated hypertension is modeled by applying a tourniquet on the carotid artery. Occlusion of the coronary artery (60 and 120 min for 12 days) induces ischemic stress. Brain ischemia is accompanied by a decrease in plasma prostacyclin and the development of platelet hyperaggregation, which can produce thrombogenesis. The calcium antagonist nifedipine produces stress- and prostacyclin-protective effects by reducing platelet hyperaggregation and preventing thrombogenesis.
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