Effect of transfer of the chromosome 13 fragment containing gene il6st on parameters of temperature homeostasis in mice

Abstract

Mechanisms of maintenance of temperature homeostasis in warm and under effect of cold were studied in mice of AKR line and of its coherent line AKR.CBA-D13Mit76 with the changed gene i16 encoding the gp130 receptor via which IL-6 performs its action. Under thermoneutral conditions and under action of cold, there were recorded temperature parameters, total oxygen consumption, carbon dioxide release, respiratory coefficient, and electrical muscle activity. Animals of the studied lines demonstrated different reactions to equal cold effect. At cooling, all mice of the AKR line entered the state of hypothermia by decreasing metabolism. Mice of the AKR.CBAD13Mit76 line showed 2 different types of reaction: 39% of animals of this line reacted like mice of the AKR line, but the majority (61%) resisted actively to the cold action, which was manifested as a marked increase of metabolism. Taking into account the gene penetrance, this can indicate effect of the gene i16 on choice of the active (“regulated”) or passive (“dependent”) way of the organism reacting to temperature actions.