Effect of transcranial static magnetic stimulation on intracortical excitability in the contralateral primary motor cortex

Abstract

Transcranial static magnetic stimulation (tSMS) is a new technique of non-invasive brain stimulation using a small, high-powered neodymium magnet placed on the scalp. It can reduce cortical excitability below the magnet. The aim of this study was to investigate the effect of tSMS on the intracortical excitability of the primary motor cortex (M1) contralateral to the M1 where the magnet was placed. Fourteen right-handed healthy subjects participated in this experiment. TSMS was applied over the left M1 for 20 min. Single-pulse and paired-pulse transcranial magnetic stimulation (TMS) was applied over the right M1 to assess corticospinal excitability, short-latency intracortical inhibition (SICI), and intracortical facilitation (ICF) before and immediately after the intervention. ICF decreased significantly after tSMS, whereas corticospinal excitability and SICI did not change. This study suggests that tSMS applied over the M1 for 20 min has a remote modulatory effect on the interneuronal facilitatory circuit in the contralateral M1. The ability of tSMS to modulate neuronal activities in the remote cortex could expand the possibility of its clinical use.