Abstract
UMIN000028224; https://upload.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000032305.
Highlights
Schizophrenia patients elicit a wide range of psychopathology, including psychotic symptoms, mood symptoms, and cognitive impairment [1,2,3]
In a previous open trial, we demonstrated the ability of transcranial direct current stimulation (tDCS) to improve functional capacity, as well as depressive symptoms, in patients with schizophrenia [22]
For the UCSD Performance-based Skills Assessment-Brief (UPSA-B), Brief Assessment of Cognition in Schizophrenia (BACS), and Positive and Negative Syndrome Scale (PANSS), we will use analysis of covariance regarding each value at baseline as a covariate
Summary
Schizophrenia patients elicit a wide range of psychopathology, including psychotic symptoms, mood symptoms, and cognitive impairment [1,2,3]. Two electrodes are placed over the scalp, through which anodal and cathodal stimulation increases and decreases cortical excitability, respectively With this mechanism, tDCS has been suggested to modulate corticosubcortical/corticocortical pathways [10, 11]. In a previous open trial, we demonstrated the ability of tDCS to improve functional capacity, as well as depressive symptoms, in patients with schizophrenia [22]. Since this was a pilot study with a single arm, conducting a controlled trial is desirable. We present a study protocol for a randomized controlled trial designed to evaluate the efficacy of tDCS on functional capacity in patients with schizophrenia
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