Abstract
ABSTRACTObjectives: To analyze the effectiveness of intravenous (IV) tranexamic acid (TA) in reducing blood loss in total knee arthroplasty (TKA).Method: The population sample was composed of patients with a diagnosis of primary knee osteoarthritis. The patients undergoing TKA were divided in two groups. Group A: comprised patients who used IV TA and B group, formed by patients who did not use TA in the intra or post-operative period. For descriptive analysis, quantitative variables were represented by mean and standard deviations when their distribution was normal and interquartile ranges and medians for non-normal variables.Results: The mean age of patients was 68 years old, most of them were female and with involvement of the left knee. Postoperatively patients who had used IV TA showed less bleeding rate and less hemoglobin rate reduction.Conclusion: The use of IV TA in TKA reduces blood loss in peri- and postoperative periods. Regarding total blood loss reduction, hemoglobin rate and need for blood transfusions, IV TA should be used routinely during TKA since it has been shown to be safe with no increase in side effects as thromboembolic events. Level of Evidence III. Retrospective Comparative Study.
Highlights
The parameters analyzed were: 1) Losses through the suction drain installed after total knee arthroplasty (TKA) in 24 and 48h; 2) Hemoglobin levels before and after the surgical procedure at 6, 24 and 48h; 3) Need for blood transfusion at 24 and 48h postoperatively, performed when hemoglobin levels were below 8 g/dl; 4) Reduction of complications such as infection, hemolytic disorders, myocardial infarction, stroke, deep vein thrombosis/ lung thromboembolism; 5) Early rehabilitation with analysis of range of motion and ability to ambulate; and 6) Reduction of hospitalization time
We evaluated 59 patients undergoing TKA performed by the same surgeon
Diabetes Mellitus was present in 10 subjects (16.9%), 3 (10%) in group A and 7 (24.1%) in group B; dyslipidemia was present in 5 patients (8.5%), 2 (6.7%) in group A and 3 (10.3%) in group B. (Figure 3) Table 3 shows the clinical data related to surgery
Summary
David Sadigursky[1,2], Daniel Andion[2], Péricles Boureau[2], Maria Cordulina Ferreira[1], Rogério Jamil Fernandes Carneiro[2], Paulo Oliveira Colavolpe[2]. Centro de Estudos em Ortopedia e Traumatologia (CEOT-COT), Orthopedic and Traumatology Clinic, Salvador, BA, Brazil
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