Effect of traditional Chinese medicine on the expression of proteinuria and inflammatory factors in diabetic kidney disease rats

Abstract

Objective To observe the effect of traditional Chinese medicine on proteinuria and inflammatory factors on the model of diabetic kidney disease rats. Methods The male SD rats were divided into the blank group, model group, treatment group, control group. The diabetic kidney disease model was induced by using the left inferior abdominal cavity. After eight weeks, we observed the changes of the rat's weight/kidney weight, blood sugar, IL-6, urine microalbumin, MCP-1 and TGF-β. Results Compared with the model group, the blood glucose (9.96 ± 3.73 mmol/L vs. 17.16 ± 5.75 mmol/L) and Proteinuria (11.73 ± 4.01 mg/L vs. 19.57 ± 8.38 mg/L, P<0.05) of the treatment group significantly decreased (P<0.05). Compared with the model group, the level of IL-6 (58.87 ± 14.69 ng/L vs. 85.22 ±12.16 ng/L) and the MCP-1 (1.52 ± 0.86 ng/L vs. 3.17 ± 1.26 ng/L) of the treatment group were significantly lower (P<0.05). Conclusions The Chinese medicine can reduce the FPG, proteinuria and the removal of serum inflammatory factors in diabetic kidney disease. Key words: Traditional Chinese drugs; Diabetic nephropathies; Proteinuria; Inflammatory factors