Abstract
Based on simulations, accuracy of the proposed correction method is good if sample preparation times do not vary or if sampling is frequent and the long and short preparation times are uniformly distributed during the PET scan time. Under these conditions, proposed method does not require measurement of the post-sampling metabolism rate, km, but the correction can be based on curve fitting of the parent fraction curve alone. If sample preparation times are generally longer or shorter for the first samples than for the late samples, the proposed correction method may correct the biases only partially, and even change the direction of the bias. If sample preparation times cannot be unified, then measurement of km might be necessary. If also the processing time, ts, for each individual sample is recorded, km could possibly be used to correct the measured parent fractions. The proposed method seems to be useful in simulating the bias introduced to analysis results in case of continuing metabolism after blood sample withdrawal. Introduction
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