Effect of Toxoplasma gondii infection on the level of NLRP3 in women with Polycystic Ovary Syndrome

Abstract

In this study, 120 women were assessed and split into four different categories. The first group included women who had been exposed to the T. gondii parasite. The second group included women possibly infected with the T. gondii parasite and PCOS. The third group was made up of women who had PCOS. The first three groups were hospitalized, while the fourth group was healthy. Blood was drawn from all groups, serum was isolated, and the level of NLRP3 was measured for all groups. The present investigation displayed that the concentration of NLRP3 in women infected with T. gondii parasite and polycystic syndrome increased significantly (P<0.05) (0.2250 + 6.698 ng/ml) compared to women infected with polycystic ovary syndrome (0.2141 +5.114 ng/ml) and women infected with the parasite (0.2200 + 0.2200). 5.255 ng/ml) compared with the control group (0.1065 + 2.021 ng/ml). This significant increase in the level of concentration NLRP3 (0.2250 + 6.698 ng/ml) in women infected with T. gondii parasite and polycystic syndrome can be adopted as an indicator of co-prepayment, or it may be dependent as an indicator of the occurrence of polycystic ovary syndrome due to prior infection with the parasite.