Abstract
BackgroundDetox diet are known as a popular dieting strategies that helps toxins elimination and weight manage but there is very little clinical evidence. The Wellnessup diet (WD) used in the present study designed as a healthy meals based on organic plant based diets including various vegetables, fruits, whole grains, nuts and phytonutrients.MethodsTo evaluate the effects of 4 week intake of the WD on toxic trace element detoxification, body fat reduction, and safety parameters. Forty-five women with body mass index (BMI) of 23.5–30 kg/m2 were recruited. Thirty of them were assigned 1:1 to the test group (WD, 15 subjects) and control group 1 (calorie-restricted diet, CRD, 15 subjects) in a single blind and randomized, and the remaining 15 subjects were assigned to control group 2 (maintaining regular diet, MRD). The primary outcome were toxic trace element levels in hair (29 types of heavy metals), and the secondary outcomes were changes in anthropometric and urinary organic acids.ResultsThe levels of four toxic trace elements in hair decreased in the WD group after the diet compared to before the diet. Ni, Rh, Sn, and Ga were significantly lower in the WD group than in the CRD or MRD group (p < 0.05). At the end of the trial, both WD and CRD groups had lower BMI, Waist Circumference(WC), Hip Circumference(HC) and WHR compared to the baseline values (p < 0.05). Compared to the WD group, the CRD group had a greater mean change (p < 0.05) from the baseline for weight loss (− 3.22 ± 0.48 kg vs − 1.88 ± 0.95 kg vs) and fat free mass (− 2.08 kg vs − 1.09 kg). The weight, BMI, body fat mass, fat free mass, WC, and HC of the CRD group were significantly decreased compared to the MRD (p < 0.05). No significant changes in any safety parameter were observed.ConclusionsUse of WD might have several beneficial effects and safety such as body fat reduction and improving some the element detoxification through caloric restriction but did not reducing body fat mass more than calorie-restricted diet.Trial registrationThis study was registered at Clinical Research Information Service (CRIS) of Republic of Korea (KCT0003002).
Highlights
With increasing industrialization, different chemicals and heavy metals have polluted the air and water, contaminating food and affecting health
Most of the environmental pollutants delivered through food are heavy metals and persistent organic pollutants (POPs)
The entire human study was conducted in accordance with the provisions of the Helsinki Declaration and the standards for clinical trial management (IGCP), and the protocol was registered at Clinical Research Information Service of Republic of Korea
Summary
With increasing industrialization, different chemicals and heavy metals have polluted the air and water, contaminating food and affecting health. Detox dieting has become a popular strategy to promote toxin removal and weight loss, enhancing health and improving quality of life. The diet detox program known as the lemon diet and hypocaloric Mediterranean diet [16, 26] were a very low-calorie diet (LCD) that allows 500 to 1000 kcal per day and is effective in reducing body weight and fat; this dietary intervention is difficult to maintain and can lead to shortages of minerals, vitamins, and dietary fiber, as well as increased binge eating and stress [27, 28]. Detox diet are known as a popular dieting strategies that helps toxins elimination and weight manage but there is very little clinical evidence. The Wellnessup diet (WD) used in the present study designed as a healthy meals based on organic plant based diets including various vegetables, fruits, whole grains, nuts and phytonutrients
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