Abstract
Objective: The objective of this study was to investigate the effect of total or partial assisted hatching on the clinical pregnancy rates in assisted reproduction technology.Study Design: This was a case-control study conducted from the beginning of January 2016 to the end of June 2017. A total of 404 cycles were included in this case-control study. Study population was divided into 3 groups: Group 1: Partial assisted hatching (n=118), Group 2: Total assisted hatching (n=81) and Control group (n=205).Results: In women of all ages, clinical pregnancy rates were similar between groups with total or partial assisted hatching compared to control group (p>0.05). The rates were also similar in subgroups of women with blastocyst or cleavage stage embryo transfers (p>0.05). Partial or total embryo hatching did not result in favorable outcome compared to control group either in women over 35 or younger than 35 years of age (p>0.05). In whole study group pregnancy rate was significantly higher in group with blastocyst stage embryo transfers (22.4 % versus 48.8%, p<0.05)Conclusion: Partial or total assisted hatching do not have any impact on the clinical pregnancy rates, no significant impact was determined in subgroup of women either.
Highlights
In women of all ages, clinical pregnancy rates were similar between groups with total or partial assisted hatching compared to control group (p>0.05)
Partial or total assisted hatching do not have any impact on the clinical pregnancy rates, no significant impact was determined in the subgroup of women either
Pregnancy rates were similar among groups with partial, total and no assisted hatching in subgroup of cases with cleavage stage embryo transfers (25.4%, 19.7%, 21.5%; respectively, p>0.05)
Summary
A successful hatching of an embryo from its zona pellucida (ZP) has significant impact on the assisted reproduction. Quick Response Code: Access this article online. How to cite this article: Bilgic BE. Effect of Total Versus Partial Assisted Hatching on the Clinical Pregnancy Rates in Assisted Reproduction Technology. Gynecol Obstet Reprod Med 2019;25(1): technology (ART) outcome [1,2,3]. Following the first report of pregnancy after assisted hatching (AH), several approaches have been introduced to improve pregnancy rates in ART [5,6,7]. Some different techniques for AH have been introduced up to date including chemical, mechanical, enzymatic, piezo-micromanipulation or laser. The technique with laser was shown to have some advantages over chemical or mechanical drilling procedures [13,14,15,16,17,18]
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