Abstract
Objectives and method: To determine the effect of total extract of milk thistle fruits on the velocity of glycine absorption in the chronic experiments under physiological condition with no operation trauma, pain, narcosis and atrophy of the small intestine. Results: In the presence of total extract of milk thistle fruits the glycine absorption velocity increases during one hour of perfusion. Absolute values of glycine absorption are higher in the presence of milk thistle fruits extract then in its absence. We observed no dissolution of perfusate with gastrointestinal fluids in the small intestine functioning part indicating that absorption of water in this fragment of small intestine prevails in the presence and in the absence of milk thistle extract both. Conclusions: Total extract of milk thistle fruits activates the velocity of absorption of glycine in the functioning fragment of the rats′ small intestine under physiological conditions.
Highlights
Due to environmental pollution, changes occur in the metabolism of the human body, and its adaptive regulatory mechanisms
Earlier in the experiments in vitro we investigated the effect of the total extract of milk thistle on glycine transport into the accumulating mucosal preparetions [7,8]
Data from different methodological conditions vary considerably, in absolute terms, and in direction, so the purpose of the work was to study the effect of the total extract of milk thistle on the absorption of glycine in the small intestine under physiological conditions in the absence of the effect of anesthesia and surgical trauma
Summary
Changes occur in the metabolism of the human body, and its adaptive regulatory mechanisms. The natural complex of biologically active substances - milk thistle - more than 2 thousand years uses to treat a range of diseases - from inflammation and arthritis to prostate carcinoma and breast cancer [3,4,5,6] The most famous it is as a hepatoprotector: on the basis of its main active ingredient - silymarin-Carsyl, Hepabene, Legalon, Galstena and other mono- and multicomponent hepatoprotective drugs were created. That allows to explore the functional activity of the small intestine in chronic experiments on non-anaesthetized animals in the absence of surgical trauma and stress - i.e., under physiological conditions Using this technique, we determined the dynamics of absorption of neutral non-essential amino acids - glycine [9]. The aim of this paper was to study the effect of the total extract of milk thistle Silybum Marianum (G.) on this process
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