Abstract
BackgroundNormal wound healing progresses through a series of interdependent physiological events: inflammation, angiogenesis, re-epithelialization, granulation tissue formation and extracellular matrix remodeling. Alterations in this process as well as the bacterial type and load on a wound may alter the wound healing rate. The purpose of this study was to evaluate the effect of topical Saccharomyces boulardii on the healing of acute cutaneous wounds, using a prospective, controlled, experimental study, with six purpose bred landrace pigs.ResultsAll wounds healed without apparent complications. Comparison of the mean 3D and 2D wound surface area measurements showed no significant difference between treatment groups as wounds decreased similarly in size over the duration of the study. A significant reduction in wound surface area was identified sooner using 3D assessments (by day 9) compared to 2D assessments (by day 12) (P < 0.001). There was no significant effect of treatment group on the number of multiple isolates or the most common isolates obtained relative to control wounds. There was no histologically appreciable difference between the wounds of the different groups.ConclusionsTopical application of Saccharomyces boulardii does not hasten wound healing or change the wounds’ microbiome under the conditions reported in this study.Electronic supplementary materialThe online version of this article (doi:10.1186/s13104-016-2012-8) contains supplementary material, which is available to authorized users.
Highlights
Normal wound healing progresses through a series of interdependent physiological events: inflammation, angiogenesis, re-epithelialization, granulation tissue formation and extracellular matrix remodeling
Bacterial colonization of wounds can contribute to inflammation and slow the wound healing process
The goal of this study was to evaluate for any treatment effect of topically applied S. boulardii to acute porcine skin wounds a model allowing wound healing in 12–14 days, with an epithelialization rate of approximately 0.05 mm/h [13]
Summary
Normal wound healing progresses through a series of interdependent physiological events: inflammation, angiogenesis, re-epithelialization, granulation tissue formation and extracellular matrix remodeling Alterations in this process as well as the bacterial type and load on a wound may alter the wound healing rate. Normal wound healing progresses through a series of interdependent physiological events: inflammation, angiogenesis, re-epithelialization, granulation tissue formation and extracellular matrix remodeling [1]. Alterations to the levels of pro- and anti-inflammatory cytokines and growth factors such as TGF-β play an important role as they can change the rate of extracellular matrix destruction and wound epithelialization [3,4,5]. Control of inflammation and bacterial colonization represent important aspects of successful wound management
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