Effect of topical melatonin 10% on the healing of infected wounds after surgery

Abstract

Melatonin remarkably accelerates wound healing in full-thickness incisional wounds. The present study aims to examine the possible antibacterial effect of topical melatonin against wound infection after surgery. Fifty-nine patients had wound infection after surgery were included in this study. One gram of tissue culture contains more than 105 colonies/gram where investigated. The culture was done after five days of surgery. Two types of bacteria were isolated; Streptococcus and Staphylococcus species. Three groups included in this study. Conventional therapy group (Fucidin 2% ointment) was considered negative control group, local melatonin 10% group, which was regarded as a positive control group and combination group of conventional therapy and local melatonin 10% groups. Treatment duration was six days; The majority hard work has been conducted to improve the antimicrobial actions of a wide range of topically used therapeutic agents, to ensure disinfection in wound sites, also, to increase wound healing processes and tissue regeneration mechanisms. The most significant cause for the manifestation and distribution of strains of bacteria which have resistant is the overuse of antibacterial drugs which initiate look for agents that may have antibacterial actions. Combination therapy gives 100% cured cases. This may be attributed to a synergistic effect between conventional treatment and melatonin therapy; therefore, the present study is to investigate the possible antibacterial effect of topical melatonin (10%) against wound infection after surgery.