Abstract
ABSTRACTPurpose: To evaluate the effect of 0.125% verapamil and 0.5% diltiazem eye drops on intraocular pressure (IOP) in steroid-induced glaucoma in rabbit eyes.Methods: A total of 18 rabbits with steroid-induced glaucoma were divided into three groups (A, B and C; n = 6 each). Right eyes in groups A, B and C received 0.5% diltiazem, 0.125% verapamil and 0.5% timolol eye drops twice daily for 12 days, respectively; whereas, left eyes received distilled water. IOP was measured with Tono-pen XL at baseline, day 4, day 8, and day 12 of treatment.Results: Both 0.5% diltiazem and 0.125% verapamil eye drops significantly reduced IOP compared to control eyes (p < 0.05). Reduction of IOP by 0.5% diltiazem, 0.125% verapamil eye drops were comparable to 0.5% timolol. No surface toxicity or systemic side effects were noted during the study period.Conclusion: Calcium channel blockers, verapamil, and diltia-zem significantly reduced IOP in rabbiteyes. This group of drugs may have a potential role in treatment of glaucomaHow to cite this article: Ganekal S, Dorairaj S, Jhanji V, Kudlu K. Effect of Topical Calcium Channel Blockers on Intraocular Pressure in Steroid-induced Glaucoma. J Current Glau Prac 2014;8(1):15-19.
Highlights
Glaucoma is second leading cause of blindness worldwide.[1]
We investigated the ocular hypo tensive role of Calcium channel blockers (CCBs) in rabbit eyes
Mean basal intraocular pressure (IOP) increased in all three groups after 40 days of twice daily treatment with 1% prednisolone acetate eye drops (Tables 1 to 3)
Summary
Glaucoma is second leading cause of blindness worldwide.[1] Characterized by progressive degeneration of retinal ganglion cells and optic nerve fibers, leading to gradual deterioration of visual field. 1,3Assistant Professor, 2Associate Professor, 4Medical Director 1Department of Ophthalmology, JJM Medical College Davangere, Karnataka, India 2Department of Ophthalmology, Mayo Clinic, Jacksonville Florida, USA 3Department of Ophthalmology and Visual Sciences, Chinese University of Hong Kong, Hong Kong 4Department of Ophthalmology, Prasad Nethralaya, Udupi Karnataka, India
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
