Abstract
Purpose: To investigate the effect of the topical decoction of Polygala tenuifolia Willd. and Polygala sibirica L. on a guinea pig model of sore and ulcer. Method: A guinea pig model of sore and ulcer was produced by Staphylococcus aureus , and 80 guinea pigs were evenly divided into eight groups, consisting of five males and five females in each group. Another 10 (5 male and 5 female) guinea pigs were used as the control group. The corresponding liquid medicine was applied to the ulcer site of the animals in each group, and administered the medicine for 6h daily with a continuous applicator for 12 d. Lysozyme content in serum was measured to determine its effects on body tissue morphology. Results: Compared with the control group, the sore skin score of guinea pigs in each dose group of decoction of Polygala tenuifolia Willd. and Polygala sibirica L. was significantly decreased. The skin showed apparent positive pathological changes and serum lysozyme concentration increased significantly (p < 0.05). Conclusion: Decoctions of the two Polygala tenuifolia species exert a good therapeutic effect on the guinea pig model of sore and ulcer for topical use. Keywords: Polygala species, Topical application, Guinea pig, Skin diseases, Lysozyme, Decoction
Highlights
Pyogenic infections are caused by various types of pathogenic factors
This paper reported the effect of Polygala tenuifolia decoction in external use on a guinea pig model of sore and ulcer
The results indicated that the decoction of Polygala tenuifolia Willd. and Polygala sibirica L. contribute to heal ulcers in guinea pigs
Summary
Pyogenic infections are caused by various types of pathogenic factors. Ancient physicians believe that skin and external diseases are mainly caused by Qi-stagnation and blood stasis, weakness of Qi and blood, and toxic pathogens [1]. This paper reported the effect of Polygala tenuifolia decoction in external use on a guinea pig model of sore and ulcer. After adding distilled water (eight times of the medicine) to simmer the solution for 60 min and filter the decoction, the filtrate obtained in the two times was merged and heated to 70 °C to further concentrate the crude drug content to 1.5, 1, and 0.5 g/mL This was followed by high-temperature sterilisation and disinfection. One day after the hair removal, according to the principle of each group containing equal number of male and female guinea pigs, 80 guinea pigs which were established successful models, were randomly divided into eight groups: a model group (MG), a group administrated with Jingwanhong (Jingwanhong group, Jwh G), groups with high, medium, and low-doses of Polygala tenuifolia decoction
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