Abstract
Background. Fibroblasts on the edges of a surgical wound are induced to synthesize collagen during the healing process which is known as fibroplasia. Objective. The aim of this study was to determine the effect of the application of different substances on fibroplasia of cutaneous surgical wounds on rats. Materials and Methods. 48 Wistar rats were divided into three groups. A surgical wound 1 cm in diameter and 1 mm in depth was created on the dorsum of each animal. The surgical wounds were submitted to the topical application of an alcoholic extract of 30% propolis, 70% alcohol, or 0.001% dexamethasone in a cream base every 12 hours. The animals were sacrificed three, seven, 14, and 28 days postoperatively. The specimens were histologically processed and stained with Masson's trichrome. The assessment of fibroplasia was performed using a scoring system: (1) 5 to 25% collagen deposition; (2) 26 to 50% collagen deposition; (3) 51 to 75% collagen deposition; (4) more than 75% collagen deposition. Results. There were statistically significant differences in collagen deposition between the substances at all postoperative evaluation times. Conclusion. Propolis and alcohol promoted greater collagen deposition in surgical wounds than dexamethasone.
Highlights
The healing process is divided into three phases: inflammatory, proliferative, and remodeling
The aim of the present study was to determine the effect of the topical application of propolis, alcohol, and dexamethasone on fibroplasia during the healing of cutaneous surgical wounds on rats through semiquantitative analysis at different postoperative evaluation times
In the group treated with dexamethasone, all wounds were ulcerated and the collagen deposition score w as 1 (Table 1)
Summary
The healing process is divided into three phases: inflammatory, proliferative, and remodeling. The deposition and maturation of collagen fibers in the granulation tissue matrix promotes the formation of conjunctive scar tissue in a process denominated fibroplasia [5,6,7,8]. Diverse substances can modulate the different phases of the healing process, including dexamethasone and propolis [7]. Fibroblasts on the edges of a surgical wound are induced to synthesize collagen during the healing process which is known as fibroplasia. The aim of this study was to determine the effect of the application of different substances on fibroplasia of cutaneous surgical wounds on rats. Propolis and alcohol promoted greater collagen deposition in surgical wounds than dexamethasone
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