Abstract
Objective We conducted a systematic review and meta-analysis to systematically evaluate the curative effect of Tongqiao Huoxue Decoction (TQHXD) combined with Western medicine treatment (WMT) on Ischemic Stroke (IS). Methods Randomized controlled trials (RCTs) of TQHXD in the treatment of IS by computer retrieval of PubMed, Embase, Web of Science, Chinese Biomedical Literature Service System, CNKI, Wanfang Database, and Weipu Database. The retrieval time was taken from the establishment of the database to July 30, 2020. Two researchers, respectively, conducted a strict evaluation of the quality of the literature and extracted the data which were then entered in the RevMan5.3 software for meta-analysis. Results 40 articles were listed, which involved 3260 patients. Meta-analysis results show that TQHXD combined with WMT can significantly reduce patients' NIHSS score, serum hypersensitivity C-reactive protein (hs-CRP), plasma viscosity, serum fibrinogen, serum total cholesterol, and serum triglycerides and improve patients' ADL-Barthel scoring and treatment efficiency. However, there is no evidence that TQHXD combined with the WMT group can significantly decrease the incidence of adverse events. Conclusion The therapeutic effect of TQHXD combined with the WMT group was significantly better than that of the WMT alone group. For the treatment of patients with IS, TQHXD combined with WMT is worthy of application and promotion.
Highlights
Depending on the latest report from the World Health Organization, stroke is the second leading cause of death worldwide [1]
Clinical randomized controlled trials (RCTs) of Tongqiao Huoxue Decoction (TQHXD) combined with Western medicine treatment (WMT) in the treatment of Ischemic Stroke (IS) are included
NIHSS Score. ere are 18 studies [16, 17, 20, 25, 27, 29,30,31, 34, 37,38,39,40,41, 44, 45, 50, 51] that reported the NIHSS scoring index. e heterogeneity test results showed that there are significant differences in heterogeneity among the 18 studies, so the random-effects model was used for meta-analysis. e results (Figure 3) showed that the NIHSS score of the TQHXD combined with WMT group was significantly different from the group of WMT alone (MD 3.11, 95% CI (2.35, 3.87), P < 0.00001)
Summary
We conducted a systematic review and meta-analysis to systematically evaluate the curative effect of Tongqiao Huoxue Decoction (TQHXD) combined with Western medicine treatment (WMT) on Ischemic Stroke (IS). Randomized controlled trials (RCTs) of TQHXD in the treatment of IS by computer retrieval of PubMed, Embase, Web of Science, Chinese Biomedical Literature Service System, CNKI, Wanfang Database, and Weipu Database. Two researchers conducted a strict evaluation of the quality of the literature and extracted the data which were entered in the RevMan5.3 software for meta-analysis. Meta-analysis results show that TQHXD combined with WMT can significantly reduce patients’ NIHSS score, serum hypersensitivity C-reactive protein (hs-CRP), plasma viscosity, serum fibrinogen, serum total cholesterol, and serum triglycerides and improve patients’ ADL-Barthel scoring and treatment efficiency. For the treatment of patients with IS, TQHXD combined with WMT is worthy of application and promotion
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