Abstract
In this study, high intensity focused ultrasound (HIFU) and PPAA (poly-propyl-acrylic acid) were combined at sublethal doses to achieve hemolysis of human erythrocytes. In a series of experiments, a suspension of erythrocytes (1A passive cavitation detection system) was utilized to monitor the acoustic emissions from the cell suspension during exposure to ultrasound. In the presence of PPAA, there is a significant increase in cavitation and hemolysis during ultrasound exposure at a pH of 6.1, but not at a pH of 7.4. PPAA is a pH-sensitive polymer, changing its conformation and its activity as the solution becomes more acidic, achieving its optimal active state at a pH of 6.1. The acoustic data and the activity of PPAA suggest that the polymer, in its active state, provides nucleation sites to the cell suspension and that cell/bubble interaction is the primary mechanism for cell damage.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
