Abstract
Abstract The effects of sodium deoxycholate, tobramycin and amiloride on the inhibitory effect (minimum inhibitory concentration) of ciprofloxacin against Pseudomonas aeruginosa (strain PAO 511 and two clinical isolates, one from a burn infection and the other from a cystic fibrosis respiratory tract infection) were examined in vitro. The method used was a macrodilution technique in Mueller-Hinton broth at 37C. Marked enhancement of ciprofloxacin activity was observed in the presence of 4.15mg/ml sodium deoxycholate, 0.4μg/ml tobramycin and 50μg/ml amiloride. It is suggested that these observations may be clinically important in the treatment of localised Pseudomonas aeruginosa infections, eg, within the respiratory tract of cystic fibrosis patients.
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