Abstract
THE habit of chewing snuff or tobacco has been associated in human beings with the occurrence of leukoplakia and cancer of the buccal mucosa1,2. In India, the chewing of dried and earth-cured tobacco along with betel nuts and slaked lime has been linked with oral cancer3,4. Differences in incidence of cancer for various communities occurs according to the site at which tobacco mass is kept in the mouth. The investigations on mice and rats recorded here show the effects of direct contact of tobacco with the buccal mucosa and effects on those organs responsible for its degradation.
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