Abstract
Our aim was to investigate the effect of TiF<sub>4</sub> solutions on mineral loss on enamel and dentine in vitro. Samples were fluoridated 1 × 5 min per day with 1.64% w/v TiF<sub>4</sub> or 2.2% w/v NaF solutions, each with a pH of 1.2, and then subjected to a cyclic de- and remineralization procedure for 5 days. Demineralization was performed for 6 × 10 min per day with citric acid (pH 2.3). In controls no fluoridation was performed. Mineral content was determined by longitudinal microradiography. Enamel mineral loss was markedly reduced by both fluoride solutions, but TiF<sub>4</sub> was significantly more effective than NaF: cumulative mineral loss on day 3 was 61.7 ± 15.0 µm in the NaF and 34.2 ± 13.1 µm in the TiF<sub>4</sub> group (p ≤ 0.001) compared with 121.0 ± 27.0 µm in the control group. Dentine mineral loss ceased after both TiF<sub>4</sub> and NaF applications (cumulative mineral loss on day 5 in controls: 61.0 ± 17.0 µm, in the TiF<sub>4</sub> group: 15.4 ± 13.4 µm and in the NaF group: 21.8 ± 11.8 µm). Both TiF<sub>4</sub> and NaF application reduced mineral loss both on enamel and dentine, which could open new possibilities for a symptomatic therapy of erosions.
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