Effect of tiotropium on lung hyperinflation in stable chronic obstructive pulmonary disease

Abstract

Objective To test the effects of tiotropium once daily on lung hyperinflation in patients with chronic obstructive pulmonary disease(COPD).Methods Forty stable COPD patients were randomized into two groups:20 patients(treatmen group)receive 18μg tiotropium once daily for 56 days,and control group(20 patients).On day 0,48,56 inspiratory capacity(IC)and functional residual capacity(FRC)were measured and compared,at the same time,dynamic intrinsic PEEP(PEEPidyn)were measured by using esophageal balloon-fipped catheter technique,respectively.Results There were no significant difference in IC,FRC,PEEPidyn between two groups(all P>0.05).On day 56,the changes continuously and have significant differences.Conclusions The use of tiotropium once daily for 56 days could obviously decrease the lung hyperinflation of stable COPD. Key words: Tiotropium; Hyperinflation; Chronic obstructive pulmonary disease