Abstract
Rationale: A history of past exacerbations (EX) is a predictor of future events in COPD patients (PT). The latest GOLD strategy divides PT into low (≤2 EX, no severe EX) and high (≥2 or ≥1 severe EX) risk categories. The current study explores the effect of tiotropium (T) and salmeterol (S) on EX in PT with a low (LR) or high risk (HR) of an EX during a 1-yr treatment period in the POET-COPD® trial (N= 3456), in which PT had a history of at least one EX within the previous yr.
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