Abstract
Dental implant with porous surface has been studied by many researchers because it has a good osseointegration. TiO2 nanotube arrays on the surface of dental implant could provide the porous surface, the space of drug loading, and better biocompatibility than bare surface. To investigate the effects of TiO2 nanotube arrays for dental implant, commercial dental implant was used and its surface was anodized to fabricate TiO2 nanotube arrays. Highly ordered TiO2 nanotube arrays were grown on the surface of dental implant. Ethylene glycol based electrolyte was used in anodic oxidation process. Anodic oxidation voltage and time were 50V and 15 min, respectively. The micro structure was observed by FE-SEM. The diameter and length of TiO2 nanotube arrays were ~60 nm and 10μm, respectively. BMP-2 was loaded in TiO2 nanotube arrays. For in-vivo testing, the dental implant with TiO2 nanotube arrays was applied to rabbit legs for 8 weeks. In dental implant with TiO2 nanotube arrays, good osseointegration properties were observed. TiO2 nanotube arrays fabricated by anodic oxidation will be very useful in the field of bone implants and bone tissue engineering.
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