Abstract
Tick-borne fever (TBF) in goats caused by Ehrlichia phagocytophila was characterized by high fever, dullness, and blood biochemical changes such as increased concentrations of bilirubin, γ-glutamyltranspeptidase, sorbitol dehydrogenase and creatinine. Reductions occurred with plasma lactate dehydrogenase, whereas no changes were observed in urea concentration, haematocrit and total plasma protein content. Changes in creatine kinase activity were variable. There was evidence of renal dysfunction in some goats which had azotaemia and dilute urine. During infection, bromsulphthalein (BSP) concentrations were higher 4 and 8 min after i.v. injection than in non-infected goats, but these results did not suggest impaired BSP excretion. Phenolsulphonthalein concentrations did not alter with TBF. The evidence from clinical pathological tests for impaired liver and kidney function in goats with TBF seems conclusive and in line with earlier reported alterations in the metabolism and excretion of drugs in affected goats.
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